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Enrollment begins for feasibility study of heart pump in patients with STEMI needing PCI

Sat, 2017-05-27 08:00
The first patients have been enrolled in an FDA-approved feasibility study to evaluate a heart pump for reduction of infarct size in patients with STEMI requiring PCI, according to a press release from Abiomed. The study will assess the safety of the heart pump system (Impella CP, Abiomed) for unloading of the left ventricle prior to PCI in patients with STEMI without cardiogenic shock.

Racial residential segregation associated with systolic BP changes

Fri, 2017-05-26 17:00
A reduction in exposure to racial residential segregation was linked to lower systolic BP, according to a study in JAMA Internal Medicine. “Our study suggests that the stress and the inadequate access to health-promoting resources associated with segregation may play a role in these increases in [BP],” David C. Goff Jr., MD, director of the division of cardiovascular diseases of the NHLBI, said in a press release. “While stress raises [BP], access to health-promoting resources, such as full-service grocery stores, recreation centers and health care clinics, is critical to keeping [BP] at healthier levels.”

Enrollment begun in study of DCB for treatment of arteriovenous fistulas in renal disease

Fri, 2017-05-26 15:00
Medtronic announced the first patient has been enrolled in a study of a drug-coated balloon to treat failing arteriovenous fistulas in patients with end-stage renal disease. According to a press release from the company, the IN.PACT AV Access DCB study was recently approved as an investigational device exemption study by the FDA.

COMPASS: Volanesorsen may lower triglyceride levels in patients with hypertriglyceridemia

Fri, 2017-05-26 13:00
PHILADELPHIA — Confirming results previously announced, patients with hypertriglyceridemia treated with volanesorsen experienced a decrease in their triglyceride levels, according to a poster presented at National Lipid Association Scientific Sessions.“We don’t have enough drugs to decrease triglyceride levels in patients with hypertriglyceridemia, and what the COMPASS study showed is that we have a wonderful new alternative to decrease triglycerides massively by 70% in patients with hypertriglyceridemia,” Ioanna Gouni-Berthold, MD, professor of medicine and senior registrar at the Center for Endocrinology, Diabetes and Preventive Medicine at the University of Cologne in Germany, said in an interview with Cardiology Today.

Few solutions available for type III hyperlipidemia, sitosterolemia, lipoprotein X disorder

Fri, 2017-05-26 11:00
PHILADELPHIA — Rare lipid disorders can be difficult to diagnose and treat, according to three presentations at the National Lipid Association Scientific Sessions.Experts presented cases and challenges related to type III hyperlipidemia, sitosterolemia and lipoprotein X disorder.

CENTERA: Novel transcatheter heart valve shows promise in aortic stenosis

Fri, 2017-05-26 09:00
Patients with severe symptomatic aortic stenosis who received a novel self-expanding transcatheter heart valve had improved outcomes, according to results presented at EuroPCR.“The Edwards Centera valve demonstrates extremely favorable early clinical safety and performance outcomes in the high surgical risk [transcatheter aortic valve replacement] population,” Didier Tchétché, MD, an interventional cardiologist at Clinique Pasteur in Toulouse, France, said in a press release. “In addition to excellent patient outcomes, the valve also offers several unique features and an innovative tissue design, all of which simplify the procedure for clinicians.”

Primary care physicians can help prevent, reverse cardiovascular diseases

Fri, 2017-05-26 07:00
Cardiovascular disease has become the leading cause of death worldwide, accounting for 31% of all deaths, or 17.5 million fatalities, globally in 2012, according to WHO. In 2016 USPSTF released guidelines recommending statin use for the primary prevention of cardiovascular disease in adults. However, many experts have argued that addressing upstream causes of cardiovascular disease might be a better option, especially since in some patients, statins cause side effects ranging from muscle achiness to gastrointestinal distress, liver toxicity and even rhabdomyolysis, a potentially life threatening breakdown of muscle tissue.

AAFP, AMA: Congressional Budget Office report shows AHCA needs work

Thu, 2017-05-25 16:51
The presidents of AAFP and AMA have unleashed a new round of criticism regarding the American Health Care Act, the bill initiating the repeal of the Affordable Care Act that narrowly passed the House earlier this month.The groups’ comments come after the Congressional Budget Office (CBO) and Joint Committee on Taxation released a report on Wednesday that indicated the House-passed version of the American Health Care Act (AHCA) would leave 14 million more people uninsured than under the present law. According to the CBO report, that number would increase to 19 million by 2020 and to 23 million by 2026. The total number of uninsured in 2026 under the age of 65 would be 51 million based on CBO projections.

AHA, other groups call for AHCA to be dropped after Congressional Budget Office score

Thu, 2017-05-25 14:00
In a joint statement, a nonpartisan coalition of patient and consumer groups wrote that the Congressional Budget Office’s new score of the American Health Care Act indicates the bill is flawed and should be discarded.

Analysis of hospital discharges: Pulmonary embolism linked with systemic lupus erythematosus

Thu, 2017-05-25 13:00
Pulmonary embolism was associated with lupus, according to results of a recently published retrospective study. Srinadh Annangi, MBBS, from the Morehouse School of Medicine in Atlanta, and colleagues performed a retrospective analysis of the National Hospital Discharge Survey data between 2001 and 2010 of patients aged 15 years and older.

Differences in CVD mortality rates between US counties decline, but still significant

Thu, 2017-05-25 11:00
Ischemic heart disease and stroke mortality rates significantly differed in counties throughout the United States, according to a study in JAMA.Less substantial variances were seen in atrial fibrillation, aortic and peripheral artery disease, rheumatic heart disease and diseases of the myocardium, researchers reported.

Triple therapy not associated with fewer ischemic events vs. DAPT in patients with AF receiving DES

Thu, 2017-05-25 11:00
Researchers found that triple therapy was not associated with decreased ischemic events but was linked to increased bleeding risk vs. dual antiplatelet therapy in patients with atrial fibrillation undergoing PCI with a drug-eluting stent.

Personalized medicine may help patients with familial hypercholesterolemia

Thu, 2017-05-25 09:00
PHILADELPHIA — Genomics, proteomics and imaging may enable a personalized medicine strategy for patients with familial hypercholesterolemia, an expert said at the National Lipid Association Scientific Sessions.Eric Sijbrands, MD, PhD, professor of internal medicine, head of the division of pharmacology, vascular and metabolic diseases and head of the Erasmus cardiovascular genetics department at Erasmus Medical Center in Rotterdam, the Netherlands, said a personalized medicine approach could work in the familial hypercholesterolemia (FH) population, but “prospective testing is needed to identify the FH mutation and calculate a genomic risk score to guide an individual treatment plan. We should monitor the treatment effect with peptides and check this with coronary CTA.”

Obstructive sleep apnea could lead to atrial fibrillation

Thu, 2017-05-25 05:46
Patients with obstructive sleep apnea may be at greater risk for atrial fibrillation, according to findings recently presented at the American Thoracic Society International Conference. “Evidence for a causal relationship between obstructive sleep apnea (OSA) and atrial fibrillation (AF) is limited and conflicting,” Tetyana Kendzerska, MD, MSc, PhD, Institute of Health Policy, Management and Evaluation, University of Toronto, and colleagues wrote.

Death, CV events similar with bivalirudin, heparin for radial PCI

Wed, 2017-05-24 17:30
In patients undergoing transradial PCI for STEMI, there was no significant difference in the rate of composite of death, MI and stroke whether patients received anticoagulation with bivalirudin or unfractionated heparin, according to a study published in JACC: Cardiovascular Interventions.

Congressional Budget Office estimates $119 billion in savings over 10 years for House-passed AHCA

Wed, 2017-05-24 17:17
The Congressional Budget Office — a non-partisan scoring agency — and the staff of the Joint Committee on Taxation released its cost estimate for the House-passed version of the American Health Care Act and estimated $119 billion in net savings from 2017 to 2026 for the proposed health care plan. Republicans needed the bill to shave off $2 billion from the federal deficit over the decade span for it to be considered under the reconciliation process in the Senate.

Less sleep may increase mortality risk in adults with metabolic syndrome

Wed, 2017-05-24 17:00
In individuals with metabolic syndrome, short sleep duration during a 1-night sleep lab was associated with increased risk of mortality vs. those with longer sleep duration, according to recent findings. “Although there is a clear association between the [metabolic syndrome] and sleep-disordered breathing, the association of sleep duration with [metabolic syndrome] and its role in predicting mortality is still poorly understood,” Julio Fernandez-Mendoza, PhD, CBSM, of the Sleep Research and Treatment Center at Penn State University College of Medicine and Penn State Milton S. Hershey Medical Center in Hershey, Pennsylvania, and colleagues wrote. “Sleep duration has been shown to be associated with specific cardiometabolic risk factors and mortality; however, studies examining [metabolic syndrome] have reported modest and inconsistent effects.”

Infections, chronic hypertension increase risk for stroke in women with preeclampsia

Wed, 2017-05-24 17:00
Chronic hypertension, infections, underlying prothrombotic conditions and coagulopathies increased risk for pregnancy-associated stroke in women with preeclampsia, according to findings published in Stroke. “Preeclampsia is a very complex disorder that’s not completely understood,” Eliza Miller, MD, a vascular neurology fellow at NewYork-Presbyterian Hospital/Columbia University Medical Center, said in a press release. “Our study sought to discover if there are other risk factors or clues that may help identify the women with preeclampsia who are at the highest risk for pregnancy-related stroke. We were looking for risk factors that could be prevented or treated.”

Prescription drug prices rose nearly 10% in 2016

Wed, 2017-05-24 15:20
The cost of prescription drugs increased by 8.77% last year, the fourth consecutive year drug prices have gone up, according to data from the Truveris National Drug Index. The company further stated the 2016 increase represents an average annual price increase of 9.98% over the last year 3 years. This report underscores several highly publicized efforts to address drug costs. In March, President Donald J. Trump said one of his principles in replacing the Affordable Care Act was to limit unnecessary procedures that cause health insurance and prescription drug costs to rise.

AKI-MATRIX: PCI with radial access reduces risk for acute kidney injury vs. femoral access

Wed, 2017-05-24 14:31
The use of radial access compared with femoral access was linked to reduced incidence of postprocedural acute kidney injury in patients with ACS who underwent invasive management, according to a presentation at EuroPCR. “Among patients with ACS who were managed invasively, the use of [radial access] was significantly associated with a reduced occurrence of [acute kidney injury] compared with [femoral access],” study presenter Bernardo Cortese, MD, from the department of medicine at Ospedale Fatebenefratelli in Milan, and colleagues wrote in the study, which was simultaneously published in the Journal of the American College of Cardiology.